Getting a venture underway is often easier than keeping it going and  growing. At each major stage from start-up to sustainable success,  entrepreneurs face tough questions about shifting gears, making major  changes, and letting go of people, partners, and products. For new  businesses, inability or unwillingness to change can land them in the  statistics about high failure rates at the five-year mark. For  non-profits, clinging to the past can lead to marginality and  stagnation. 
To keep an enterprise on track while facing the often-pleasant  challenge of growth requires making sometimes-painful adjustments in  these five areas:
The People. One of the hardest questions is when to  change the people — not just individually, but the whole mix. Founders  often start with friends and true believers who work hard because of  zeal for the cause or hope for future returns. They occupy multiple  overlapping roles. But do the people with single-digit badge numbers or  members of the founding generation have the skills the organization  needs as it creates routines and requires depth in every specialty? Who  can make the cut? A winery I knew from its beginning kept the original  group longer than the business could afford, and loyalty got in the way  of bringing in experienced people "above" the people who felt they were  founders and thus privileged to call the shots. Raise a glass to  courageous leaders willing to tell people they must either grow or go.
Finances. Whether the original source of funds is  venture capital or venture philanthropy, an investor base or a donor  base, each growth phase challenges organizations to shift assumptions  and thus change practices. Perhaps investors expect customers to take  over as funders of growth by paying more (or paying at all), a challenge  dot-com companies faced in the first Internet wave and social media  companies face now. Non-profits also outgrow friends-and-family angels  or local sources and must find sustainable revenue and capital sources.  How do you move from being discretionary nice-to-have in a portfolio to  essential-to-fund? Where are the new sources appropriate to a new,  larger size? A multi-site non-profit went from local businesses close to  the founding city to national funders in government and foundations to a  revenue model replicable in every site through ongoing school budgets  on a fee-for-service basis.
Partners and Allies. The best organizations are  attuned to the need for key external relationships that provide  resources and support. At the same time, entrepreneurs do not want to be  captive to the needs and desires of their first distribution partners,  component suppliers, source of talent, or marketing allies. It is tricky  to know how to nurture and draw benefits from key partners without  being subsumed by them — or subject to damage if they stumble — and, at  the same time, add to a partner set without creating conflicts. Which  partners should be downplayed or replaced as the organization grows? How  can key relationships be managed to lessen dependence while seeking  new, more relevant, allies? And with growth comes the need for entirely  new types of relationships — which is why Facebook now has an enlarged  Washington office.
Organizational Culture. Are you making explicit what  the organization stands for in tangible ways that can be transmitted  and endure? Are you on guard against drifting away from the culture?  Numerous studies, including my own, show that an emphasis on  organizational culture is associated with continuing excellence. Values,  stories, artifacts, and rituals provide a source of identity that makes  the organization feel the same, in pursuit of the same mission even  while everything else changes. Culture provides internal glue. As an  organization grows, what was once informal must be documented, codified,  memorialized, and passed on to new people. Savvy entrepreneurs ensure  that their organizations are built to last by stressing culture. At  every stage, they invest in preserving fundamental values and principles  while adding new iconic stories that reflect them.
Outcomes and Impact. What results are being  produced, for whom, and are these sufficient? In the beginning it's  enough to show that it can be done at all — to address a good cause or  to prove that something works in a handful of markets. In the next  phase, you might look at growth indicators — we did more this year than  last year. Recall the signs that McDonald's posted outside its stores  during its rapid growth phase, heralding how many millions of hamburgers  had been served.  Sooner or later a new question arises: Are you making  a difference that makes the venture more essential? 
Ventures that go from proof of concept to "permanent" player have  become icons, household names, or must-have players because they can  show differentiated user, recipient, or national benefits — that they  have impact not just on their immediate customers but on the entire  industry. We all know that success provokes imitation. As the  organization grows, its distinctiveness gets harder to maintain. But  often many in and around the organization come to believe that existence  is a sufficient sign of importance — a trap particularly for  non-profits. Asking the "so what if we weren't here?" question about  making a difference can provoke soul-searching and strategy change.
The bottom line: In addition to the challenges of innovation to  ensure new offerings and new capabilities, entrepreneurs and  organization founders must also be alert to the ways that the  organization itself changes as a result of growth. It is important to  anticipate those developments and ask the five big questions at every  stage in order to get ahead of change and master it.
(Source: http://www.bloomberg.com/news/2011-06-13/five-tough-questions-every-entrepreneur-must-ask-about-growth.html) 
